Function of vascular cells in patients with type 2 diabetes<\/h3>\n\n\n\n
It is known that the proper function of vascular cells is impaired in a number of diseases, particularly in patients with type 2 diabetes. In these patients, vascular cells play an important role in the progression of their diabetes. Furthermore, it has been shown that mechanical stimulation of the vessels (shear stress) and NO release from the vascular cells are reduced in diabetics, which impairs blood microcirculation. It was also found that there is a close connection between the healthy function of vascular cells and the action of insulin, a hormone involved in glucose regulation. Poor vascular cell function ultimately leads to severe complications in organs where microcirculation is particularly important:<\/p>\n\n\n\n
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- EYES: Damage to the retina, with vision loss and even blindness.<\/li>\n\n\n\n
- HEART: Infarctions due to poor perfusion of the coronary vessels.<\/li>\n\n\n\n
- LOWER EXTREMITIES: Slow-healing wounds that can lead to amputation of the affected body parts.<\/li>\n\n\n\n
- KIDNEYS: They decrease in function, making dialysis or a kidney transplantation necessary.<\/li>\n\n\n\n
- BRAIN: Occurrence of strokes (cerebral vascular damage).<\/li>\n<\/ul>\n\n\n\n<\/div>\n\n\n\n
Worldwide, more than 537 million people are affected by type 2 diabetic complications; particularly in so-called developed countries, an amputation due to diabetes occurs every 30 seconds. In France, for example, 8,000 amputations are performed on diabetics every year, 12,000 are hospitalized for a heart attack, and 4,000 new cases of severe kidney failure occur. It is therefore obvious that any therapy that improves microcirculation and maintains blood flow in the microvessels of vital organs is sensible and suitable for reducing diabetic complications.<\/p>\n\n\n\n
<\/div>\n\n\n\nSTENDO\u00ae<\/sup> Body pulse therapy\u00ae<\/sup> \u2013 an effective treatment method<\/h3>\n\n\n\n
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<\/figure>\n<\/div>\n\n\n\n\nThe French company STENDO\u00ae<\/sup> has tackled precisely this issue (STENDO = STimulation ENDOth\u00e9liale) and brought a patented pulse therapy device, the STENDO\u00ae Body, to the market. The sophisticated pulse therapy\u00ae<\/sup> serves to stimulate the blood circulation. The STENDO\u00ae Body consists of a console connected to a pneumatic trouser cuff with integrated gel cushions, which applies pulsating compressions and decompressions synchronously with the heartbeat. This cardiosynchronous pulse therapy\u00ae<\/sup> naturally increases the heart rate in the body, thereby simulating increased physical movement. Due to the increased \u201etraining activity\u201c of the vessels, the endothelium is stimulated and releases more nitric oxide (NO). Through the increased blood flow, the NO is distributed throughout the body and the vessels are dilated.<\/p>\n<\/div>\n<\/div>\n\n\n\n
<\/div>\n\n\n\nEffectiveness of STENDO\u00ae pulse therapy\u00ae scientifically proven in type 2 diabetes patients!<\/h3>\n\n\n\n
Two different test centers conducted the randomized, controlled cross-over studies as follows:<\/p>\n\n\n\n
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<\/figure>\n<\/div>\n\n\n\n\nStudy 1:<\/h5>\n\n\n\n
The aim of the study was to evaluate the acute effects in 16 patients. The effects of a STENDO\u00ae<\/sup> DSCD sessions (Verum session, 20 minutes) were evaluated in comparison to a subsequent control session (simulated DSCD session, 20 minutes) conducted after a two-week washout period, or vice versa (CHU Jean Verdier, Professor Paul Valensi).
Interstitial glucose (CGM) and skin blood flow (laser Doppler, Periflux) were measured and continuously recorded on the forearm before, during, and after the DSCD verum or simulated sessions. Endothelial function was assessed before and after the sessions.<\/p>\n<\/div>\n<\/div>\n\n\n\n<\/div>\n\n\n\n\n\n<\/figure>\n<\/div>\n\n\n\n\nStudy 2:<\/h5>\n\n\n\n
The second study evaluates the chronic effects in 38 patients. The effects of three one-hour DSCD sessions per week over a period of 3 months were evaluated in comparison to a subsequent control phase of 3 months (without DSCD sessions), with the two periods separated by a washout period of 4 to 6 weeks, or vice versa, i.e., control period followed by the DSCD period (Clermont-Ferrand University Hospital, Professor Martine Duclos). Examinations of endothelial function, microcirculation, metabolism, body composition, and physical activity were performed before and after each 3-month period.<\/p>\n<\/div>\n<\/div>\n\n\n\n
<\/div>\n\n\n\nIn both studies, skin microcirculation and endothelial reactivity were measured using laser Doppler on either the forearm or the palm of the hand, as these sites reflect the functions and alterations of microcirculation in other organs and tissues. 1) 2) 3)<\/sup><\/p>\n\n\n\n
<\/div>\n\n\n\nResults<\/h3>\n\n\n\n
The two studies led to the following results, which are presented in the linked English Summary<\/strong><\/a> be explained in detail:<\/p>\n\n\n\n
\n\n<\/figure>\n<\/div>\n\n\n\n\nImprovement of cell functions<\/h5>\n\n\n\n
STENDO\u00ae reduces lower limb volume in patients with significant fluid retention. Therefore, STENDO\u00ae Body has been successfully used in therapy since 2018.
In patients with type 2 diabetes:<\/p>\n\n\n\n- \n
- \u00a0a single 20-minute STENDO\u00ae session increases microcirculation, which then continues for more than 30 minutes after the end of the session.<\/li>\n\n\n\n
- \u00a0specific tests have shown that the function of the vascular cells improves significantly after several sessions.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<\/div>\n\n\n\n\n\n<\/figure>\n<\/div>\n\n\n\n\n
Secondary improvements<\/h5>\n\n\n\n
Furthermore, it has been demonstrated that the improvement of vascular function also has a positive effect on biological and physical parameters that otherwise deteriorate in diabetics. Here we are talking about the following positive effects:<\/p>\n\n\n\n
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- Decrease in fluid retention.<\/li>\n\n\n\n
- Faster drop in blood sugar levels after a meal.<\/li>\n\n\n\n
- Improvement of blood lipid levels.<\/li>\n\n\n\n
- Improvement of vitality and general physical performance.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<\/div>\n\n\n\n
Conclusions<\/h2>\n\n\n\n
It is the first time that a device (Stendo\u00ae) has been proven capable of improving the vascular cell function of type 2 diabetes patients and microcirculation as follows.
1. The improvement of vascular function by Stendo\u00ae is highlighted without causing any negative effects.
2. The studies conducted with Stendo\u00ae pulsetherapy underline the value of this new treatment method for improving microcirculation in type 2 diabetics and reducing vascular complications, which can lead in particular to foot ulcers and even amputations.<\/p>\n\n\n\nAll listed effects of STENDO\u00ae<\/sup> Pulse therapy\u00ae in diabetics has been demonstrated in two clinical trials. Click here for the Original report.<\/a><\/strong><\/p>\n\n\n\n
1) Holowatz LA, Thompson-Torgerson CS, Kenney WL. The human cutaneous circulation as a model of generalized microvascular function. J Appl Physiol 2008;105:370-37
2) Rossi M, Carpi A, Galetta F, Franzoni F, Santoro G. The investigation of skin blood flow motion: a new approach to study the microcirculatory impairment in vascular diseases? Biomed Pharmacother 2006;60:437-44
3) Khan F, Patterson D, Belch JJ, Hirata K, Lang CC. Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography. Clin Sci (Lond.) 2008;115:295-300<\/p>\n\n\n\n<\/div>\n\n\n\n
\n\n\n\n<\/div>\n\n\n\nDo you have questions about the topic?<\/h2>\n\n\n\n
We are happy to provide you with further information and answer your questions personally.<\/p>\n\n\n\n
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